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- Title
Adenosine and Its Receptors in the Pathogenesis and Treatment of Inflammatory Skin Diseases.
- Authors
Chen, Luxia; Lei, Xuan; Mahnke, Karsten
- Abstract
Inflammatory skin diseases highlight inflammation as a central driver of skin pathologies, involving a multiplicity of mediators and cell types, including immune and non-immune cells. Adenosine, a ubiquitous endogenous immune modulator, generated from adenosine triphosphate (ATP), acts via four G protein-coupled receptors (A1, A2A, A2B, and A3). Given the widespread expression of those receptors and their regulatory effects on multiple immune signaling pathways, targeting adenosine receptors emerges as a compelling strategy for anti-inflammatory intervention. Animal models of psoriasis, contact hypersensitivity (CHS), and other dermatitis have elucidated the involvement of adenosine receptors in the pathogenesis of these conditions. Targeting adenosine receptors is effective in attenuating inflammation and remodeling the epidermal structure, potentially showing synergistic effects with fewer adverse effects when combined with conventional therapies. What is noteworthy are the promising outcomes observed with A2A agonists in animal models and ongoing clinical trials investigating A3 agonists, underscoring a potential therapeutic approach for the management of inflammatory skin disorders.
- Subjects
ADENOSINES; SKIN diseases; IMMUNOMODULATORS; CONTACT dermatitis; ADENOSINE triphosphate; PATHOGENESIS
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 11, p5810
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25115810