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- Title
Neurobehavioral Mechanisms Influencing the Association Between Generativity, the Desire to Promote Well-Being of Younger Generations, and Purpose in Life in Older Adults at Risk for Alzheimer's Disease.
- Authors
Walker, Caitlin S; Li, Linda; Baracchini, Giulia; Tremblay-Mercier, Jennifer; Spreng, R Nathan; Group, The PREVENT-AD Research; Geddes, Maiya R
- Abstract
Objectives Generativity, the desire and action to improve the well-being of younger generations, is associated with purpose in life among older adults. However, the neurobehavioral factors supporting the relationship between generativity and purpose in life remain unknown. This study aims to identify the functional neuroanatomy of generativity and mechanisms linking generativity with purpose in life in at-risk older adults. Methods Fifty-eight older adults (mean age = 70.8, SD = 5.03, 45 females) with a family history of Alzheimer's disease (AD) were recruited from the PREVENT-AD cohort. Participants underwent brain imaging and completed questionnaires assessing generativity, social support, and purpose in life. Mediation models examined whether social support mediated the association between generativity and purpose in life. Seed-to-voxel analyses investigated the association between generativity and resting-state functional connectivity (rsFC) to the ventromedial prefrontal cortex (vmPFC) and ventral striatum (VS), and whether this rsFC moderated the relationship between generativity and purpose in life. Results Affectionate social support mediated the association between generative desire and purpose in life. Generative desire was associated with rsFC between VS and precuneus, and, vmPFC and right dorsolateral prefrontal cortex (rdlPFC). The vmPFC–rdlPFC rsFC moderated the association between generative desire and purpose in life. Discussion These findings provide insight into how the brain supports complex social behavior and, separately, purpose in life in at-risk aging. Affectionate social support may be a putative target process to enhance purpose in life in older adults. This knowledge contributes to future developments of personalized interventions that promote healthy aging.
- Subjects
ALZHEIMER'S disease risk factors; BRAIN anatomy; LIFE; RISK assessment; RESEARCH funding; BRAIN; QUESTIONNAIRES; DESCRIPTIVE statistics; LONGITUDINAL method; HEALTH promotion; SOCIAL support; FACTOR analysis; WELL-being; SPINAL cord; INTERGENERATIONAL relations
- Publication
Journals of Gerontology Series B: Psychological Sciences & Social Sciences, 2024, Vol 79, Issue 6, p1
- ISSN
1079-5014
- Publication type
Article
- DOI
10.1093/geronb/gbae060