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- Title
Cytokine and chemokine responses in pediatric patients with severe pneumonia associated with pandemic A/H1N1/2009 influenza virus.
- Authors
Matsumoto, Yuji; Kawamura, Yoshiki; Nakai, Hidetaka; Sugata, Ken; Yoshikawa, Akiko; Ihira, Masaru; Ohashi, Masahiro; Kato, Tomochika; Yoshikawa, Tetsushi
- Abstract
ABSTRACT Severe pneumonia and leukocytosis are characteristic, frequently observed, clinical findings in pediatric patients with pandemic A/H1N1/2009 influenza virus infection. The aim of this study was to elucidate the role of cytokines and chemokines in complicating pneumonia and leukocytosis in patients with pandemic A/H1N1/2009 influenza virus infection. Forty-seven patients with pandemic A/H1N1/2009 influenza virus infection were enrolled in this study. Expression of interleukin (IL)-10 ( P = 0.027) and IL-5 ( P = 0.014) was significantly greater in patients with pneumonia than in those without pneumonia. Additionally, serum concentrations of interferon-γ ( P = 0.009), tumor necrosis factor-α ( P = 0.01), IL-4 ( P = 0.024), and IL-2 ( P = 0.012) were significantly lower in pneumonia patients with neutrophilic leukocytosis than in those without neutrophilic leukocytosis. Of the five serum chemokine concentrations assessed, only IL-8 was significantly lower in pneumonia patients with neutrophilic leukocytosis than in those without leukocytosis ( P = 0.001). These cytokines and chemokines may play important roles in the pathogenesis of childhood pneumonia associated with A/H1N1/2009 influenza virus infection.
- Subjects
PNEUMONIA in children; H1N1 influenza; LEUCOCYTOSIS; CHILD patients; CYTOKINES; CHEMOKINES; INTERLEUKINS; TUMOR necrosis factors
- Publication
Microbiology & Immunology, 2012, Vol 56, Issue 9, p651
- ISSN
0385-5600
- Publication type
Article
- DOI
10.1111/j.1348-0421.2012.00489.x