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- Title
Adalimumab for treatment of severe ulcerative sarcoidosis.
- Authors
Vetos, Develyn; Wu, Dominic J.; Downing, Malia B.; Rajpara, Anand
- Abstract
Ulcerative sarcoidosis is a rare variant of cutaneous sarcoidosis that may present as ulceration with necrotic yellow plaques on the lower extremities, face, arms, trunk, or genital area. Adalimumab, a human monoclonal anti-TNF antibody, is an emerging treatment for recalcitrant cutaneous sarcoidosis. We describe severe ulcerative sarcoidosis in a 60-year-old woman with chronic ulcerative necrobiosis lipoidica-like plaques on her left arm for over 20 years. Her condition had not responded to previous treatments with hydroxychloroquine, methotrexate, and sulfasalazine. After a four-month course of adalimumab therapy in addition to pentoxifylline and prednisone with taper, the patient had significant improvement in her skin disease.
- Subjects
ADALIMUMAB; SARCOIDOSIS treatment; MONOCLONAL antibodies; HEALTH of older women; HYDROXYCHLOROQUINE
- Publication
Dermatology Online Journal, 2021, Vol 27, Issue 6, p1
- ISSN
1087-2108
- Publication type
Article
- DOI
10.5070/D327654058