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- Title
Superovulation does not affect the endocrine activity nor increase susceptibility to carcinogenesis of uterine and mammary glands of female offspring in mice.
- Authors
Gao, Zong; Zhang, Gang; Yu, Jing; Lu, Xi-Lan; Li, Jun-Tao; Zhang, Jian-Min
- Abstract
Purpose: To evaluate the dual effects of superovulation on the endocrine activity and susceptibility to carcinogenesis of uterine and mammary glands of female offspring in mice Method: The mice were superovaluted. The relative uterine weight, ERα protein expression, and endocrine activity of female offspring (F1 generation and F2 generation) were measured. Furthermore, proliferative lesion of uterine and mammary glands of female offspring (F1 generation and F2 generation) was assessed by histopathologic examinations. Results: There were no significant differences in relative uterine weight, ERα protein expression, incidence of proliferative lesion in mammary glands, and incidence of atypical hyperplasia, adenocarcinoma, and squamous metaplasia in uterine among the offspring (F1 generation and F2 generation) in each group. Likewise, there were no significant intergroup differences in the serum levels of sex related hormones. Conclusions: No significant alterations were found in the endocrine activity and susceptibility to carcinogenesis of uterine and mammary glands of female offspring in mice produced by superovaluted oocytes compared with those of naturally conceived offspring.
- Subjects
OVULATION; ENDOCRINE gland physiology; DISEASE susceptibility; CARCINOGENESIS; MAMMARY glands; LABORATORY mice
- Publication
Journal of Assisted Reproduction & Genetics, 2014, Vol 31, Issue 9, p1243
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-014-0295-z