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- Title
The association of urinary pentosidine levels with the prevalence of osteoporotic fractures in postmenopausal women.
- Authors
Shiraki, Masataka; Kashiwabara, Shoji; Imai, Takumi; Tanaka, Shiro; Saito, Mitsuru
- Abstract
To evaluate whether or not the urinary pentosidine level has clinical value in the assessment of the osteoporotic fracture risk, a novel ELISA for pentosidine was used in clinical samples. This study employed a cross-sectional design to analyze a subset of postmenopausal women in the Nagano Cohort Study. A total of 517 urine samples were analyzed using an ELISA system, which can measure urinary pentosidine without hydrolysis. Patients were asked about their history of non-vertebral osteoporotic fracture and the prevalence of vertebral fracture was semi-quantitatively assessed on X-ray films. A 10-year increase in age was related to a 1.09-fold increase in the urinary pentosidine level (95% CI 1.05-1.13, P < 0.001), prevalent fracture (+) was related to a 1.10-fold increase in the urinary pentosidine level (95% CI 1.03-1.18, P = 0.006). Patients with prevalent fracture who had a normal bone mineral density (BMD) showed higher pentosidine levels (median 34.3 pM/mg Cr) than patients with a low BMD without fracture (median 31.4 pM/mg Cr). A multivariable logistic regression analysis revealed that urinary pentosidine was significantly associated with the prevalence of fracture after adjustment for known risk factors for fracture (odds ratio 1.92, 95% CI 1.09-3.37, P = 0.023). The present results indicated a significant association between urinary pentosidine and fracture after adjustment for age and BMD, suggesting that urinary pentosidine may be useful for assessing the fracture risk in postmenopausal women.
- Subjects
ADVANCED glycation end-products; HYDROLYSIS; OSTEOPOROSIS; DIAGNOSIS of bone fractures; BONE density
- Publication
Journal of Bone & Mineral Metabolism, 2019, Vol 37, Issue 6, p1067
- ISSN
0914-8779
- Publication type
journal article
- DOI
10.1007/s00774-019-01017-9