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- Title
Characteristic endoscopic findings of gastric adenocarcinoma of fundic-gland mucosa type.
- Authors
Imamura, Kentaro; Yao, Kenshi; Nimura, Satoshi; Tanabe, Hiroshi; Kanemitsu, Takao; Miyaoka, Masaki; Ono, Yoichiro; Ueki, Toshiharu; Iwashita, Akinori
- Abstract
Background and study aims: Gastric adenocarcinoma of fundic-gland type (GA-FG) was first proposed as a new entity of gastric adenocarcinoma in 2010. Subsequently, gastric adenocarcinoma of fundic-gland mucosa type (GA-FGM) was reported as a subtype of gastric adenocarcinoma. This study aimed to investigate the endoscopic findings of GA-FGM and to evaluate the differences between GA-FGM and GA-FG. Patients and methods: This was a single-center retrospective study. Participants were selected from patients with gastric cancer treated at Fukuoka University Chikushi Hospital, between September 2007 and May 2020. Patients histologically diagnosed with GA-FGM or GA-FG were enrolled, and endoscopic findings were analyzed in detail. Results: A total of 12 GA-FGM lesions (12 patients) and 14 GA-FG lesions (13 patients) were analyzed. The two lesion types showed similar features: most lesions were of elevated type, located in the upper stomach, and developed in the stomach without Helicobacter pylori infection. On conventional endoscopy using the dye-spraying method, well-demarcated fine granular areas were observed in 7 GA-FGM lesions (58%) but not in any GA-FG lesions, with a significant difference between the two groups (P = 0.001). Magnifying endoscopy with narrow-band imaging (NBI) showed that 11 GA-FGM lesions (92%) met the diagnostic criteria for cancer according to the vessel plus surface classification system, whereas none of the GA-FG lesions met the same criteria (0%, 0/14) (P = 0.001). Conclusion: Our results suggest that magnifying endoscopy with NBI is a potentially useful method for the diagnosis of GA-FGM.
- Subjects
ADENOCARCINOMA; MUCOUS membranes; ENDOSCOPY; DIAGNOSIS; STOMACH cancer
- Publication
Gastric Cancer, 2021, Vol 24, Issue 6, p1307
- ISSN
1436-3291
- Publication type
Article
- DOI
10.1007/s10120-021-01208-2