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- Title
Tailor-made mannosylerythritol lipids: current state and perspectives.
- Authors
Saika, Azusa; Koike, Hideaki; Fukuoka, Tokuma; Morita, Tomotake
- Abstract
Mannosylerythritol lipids (MELs) are a type of glycolipid biosurfactant produced by basidiomycetous yeasts, most notably those belonging to the genera Pseudozyma and Ustilago. Mannosylerythritol lipids are environmentally friendly and possess many unique functions, such as gene delivery, bio-activation, and human skin repair, and thus have potential applications in cosmetic, pharmaceutical, agriculture, food, and environmental industries. However, MELs will require overcoming same issues related to the commercialization, e.g., expansion of the structure and function variety and cost reduction. In the past decade, various studies have attempted to tailor production of targeted MELs in order to expand the utility of these biosurfactants. Moreover, the rapid development of genomic sequencing techniques will enhance our ability to modify MEL producers. In this review, we focus on current research into the tailored production of MELs, including conventional and advanced approaches.
- Subjects
LIPID synthesis; GLYCOLIPIDS; YEAST fungi; USTILAGO; GENE delivery techniques; BIOSURFACTANT synthesis; NUCLEOTIDE sequencing; INDUSTRIAL enzymology
- Publication
Applied Microbiology & Biotechnology, 2018, Vol 102, Issue 16, p6877
- ISSN
0175-7598
- Publication type
Article
- DOI
10.1007/s00253-018-9160-9