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- Title
In Patients with Colorectal Cancer, Preoperative Serum Interleukin-6 Level and Granulocyte/Lymphocyte Ratio Are Clinically Relevant Biomarkers of Long-Term Cancer Progression.
- Authors
Shimazaki, Jiro; Goto, Yoshihisa; Nishida, Kiyotaka; Tabuchi, Takanobu; Motohashi, Gyo; Ubukata, Hideyuki; Tabuchi, Takafumi
- Abstract
Objective: To investigate the clinical significance of the serum inflammatory cytokines and the blood granulocytes/lymphocytes (G/L) ratio in patients with colorectal cancer. Methods: Forty-six patients underwent surgery for colorectal cancer. The G/L ratio and serum inflammatory cytokines including interleukin (IL)-1β, IL-6, IL-8, tumour necrosis factor-α (TNF-α), granulocyte colony-stimulating factor and macrophage colony-stimulating factor (M-CSF) were measured before surgery and correlated with the Tumour Node Metastasis classification and overall survival. Results: Serum IL-6 in T3-4, N1-2, M1 cases and cancer stages III-IV sub-groups was significantly higher than in Tis-2, N0, M0 and cancer stages 0-II sub-groups. The G/L ratio, serum M-CSF and TNF-α in T3-4 cases were significantly higher than in Tis-2 cases. Furthermore, the G/L ratio and serum IL-6 showed a significant inverse correlation with the overall survival, while the G/L ratio showed a significant positive correlation with serum IL-6, TNF-α and M-CSF. Multivariate analysis showed that the serum IL-6 level and G/L ratio were independent risk factors for poor prognosis. Conclusions: In this investigation, a pre-operative high level of serum IL-6 and the G/L ratio appeared to be significant predictive factors for cancer progression and poor prognosis. Accordingly, these variables might be clinically relevant biomarkers in patients with colorectal cancer. Copyright © 2013 S. Karger AG, Basel
- Subjects
JAPAN; RECTUM tumors; COLON tumors; ACADEMIC medical centers; BIOMARKERS; BLOOD testing; CONFIDENCE intervals; STATISTICAL correlation; CYTOKINES; GRANULOCYTES; INTERLEUKINS; LYMPHOCYTES; MULTIVARIATE analysis; STATISTICS; U-statistics; DATA analysis; EQUIPMENT &; supplies; PROPORTIONAL hazards models; DATA analysis software; PROGNOSIS
- Publication
Oncology, 2013, Vol 84, Issue 6, p356
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000350836