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- Title
Polymorphonuclear Cells Increase the Adhesion of Circulating Tumour Cells to Microvascular Endothelium.
- Authors
ten Kate, M.; ten Raa, S.; Tltulaer, P.; Aalbers, A.; Sluiter, W.; Jeekel, H.; van Eijck, C. J. H.
- Abstract
Abdominal surgical trauma provokes a systemic inflammatory reaction in which polymorphonuclear cells (PMN) are activated with the release of reactive oxygen species, mainly superoxide radicals. Activated PMN enhance tumour cell-endothelial cell interactions in vitro and therefore can be responsible for enhanced tumour recurrence after surgical trauma. Insights in the mechanism of enhanced tumor cell adhesion after surgery may lead to the development of tools to prevent this pathway of post-surgical recurrence.
- Subjects
TUMOR surgery; CANCER cells; CELL communication; CELL adhesion; CELLULAR mechanics; ENDOTHELIUM; NEUTROPHILS
- Publication
European Surgical Research, 2004, Vol 36, p58
- ISSN
0014-312X
- Publication type
Article