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- Title
A new H-2-linked class I gene whose expression depends on a maternally inherited factor.
- Authors
Lindahl, Kirsten Fischer; Hausmann, Barbara; Chapman, Verne M.
- Abstract
The maternally transmitted antigen (Mta) is expressed on the cells of most strains of mice1,2. It is a medial histocompatibility antigen3, that is, it is recognized by unrestricted cytotoxic T lymphocytes as are major H antigens, but unlike these it is a weak transplantation antigen and does not itself restrict the T-cell recognition of minor H antigens. All other medial H antigens are encoded by genes closely linked to the major histocompatibility complex3, H-2 in the mouse. By contrast, Mta appeared to follow extrachromosomal, maternal inheritance. Several substrains of NZB, NZO and non-inbred European NMRI mice are Mta-negative. Females of these strains bear only Mta− offspring, while females of the inbred Mta+ strains bear only Mta+ offspring. Repeated backcrossing from Mta+ females to NZB or NMRI males has shown that, given the right cytoplasmic genes, the chromosomal genes of these Mta− strains permit expression of Mta2. As the Mta type of a mouse cannot be influenced by embryo transfer or foster nursing2,4, we concluded that it was determined by a cytoplasmic factor (Mtf), transmitted through the egg. We now show that a gene, Hmt, closely linked to the H-2 complex, is also required for expression of Mta.
- Publication
Nature, 1983, Vol 306, Issue 5941, p383
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/306383a0