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- Title
Chemical biology probes of mammalian GLUT structure and function.
- Authors
Holman, Geoffrey D.
- Abstract
The structure and function of glucose transporters of the mammalian GLUT family of proteins has been studied over many decades, and the proteins have fascinated numerous research groups over this time. This interest is related to the importance of the GLUTs as archetypical membrane transport facilitators, as key limiters of the supply of glucose to cell metabolism, as targets of cell insulin and exercise signalling and of regulated membrane traffic, and as potential drug targets to combat cancer and metabolic diseases such as type 2 diabetes and obesity. This review focusses on the use of chemical biology approaches and sugar analogue probes to study these important proteins.
- Subjects
CHEMICAL biology; GLUCOSE transporters; CELL metabolism; INSULIN; TYPE 2 diabetes
- Publication
Biochemical Journal, 2018, Vol 475, Issue 22, p3511
- ISSN
0264-6021
- Publication type
Article
- DOI
10.1042/BCJ20170677