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- Title
Tissue sodium stores in peritoneal dialysis and hemodialysis patients determined by sodium-23 magnetic resonance imaging.
- Authors
Sahinoz, Melis; Tintara, Supisara; Deger, Serpil Muge; Alsouqi, Aseel; Crescenzi, Rachelle L; Mambungu, Cindy; Vincz, Andrew; Mason, Olivia J; Prigmore, Heather L; Guide, Andrew; Stewart, Thomas G; Harrison, David G; Luft, Friedrich C; Titze, Jens; Ikizler, Talat Alp
- Abstract
Background Tissue sodium (Na+) content in patients on maintenance hemodialysis (MHD) and peritoneal dialysis (PD) was previously explored using 23Na+ magnetic resonance imaging (23NaMRI). Larger studies would provide a better understanding of Na+ stores in patients on dialysis as well as the factors influencing this Na+ accumulation. Methods In this cross-sectional study, we quantified the calf muscle and skin Na+ content in 162 subjects (10 PD, 33 MHD patients and 119 controls) using 23NaMRI. Plasma levels of interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) were measured to assess systemic inflammation. Sixty-four subjects had repeat 23NaMRI scans that were analyzed to assess the repeatability of the 23NaMRI measurements. Results Patients on MHD and PD exhibited significantly higher muscle and skin Na+ accumulation compared with controls. African American patients on dialysis exhibited greater muscle and skin Na+ content compared with non–African Americans. Multivariable analysis showed that older age was associated with both higher muscle and skin Na+ and male sex was associated with increased skin Na+ deposition. Greater ultrafiltration was associated with lower skin Na+ in patients on PD (Spearman's ρ = −0.68, P = 0.035). Higher plasma IL-6 and hsCRP levels correlated with increased muscle and skin Na+ content in the overall study population. Patients with higher baseline tissue Na+ content exhibited greater variability in tissue Na+ stores on repeat measurements. Conclusions Our findings highlight greater muscle and skin Na+ content in dialysis patients compared with controls without kidney disease. Tissue Na+ deposition and systemic inflammation seen in dialysis patients might influence one another bidirectionally.
- Subjects
MAGNETIC resonance imaging; PERITONEAL dialysis; HEMODIALYSIS patients; CALF muscles; SODIUM
- Publication
Nephrology Dialysis Transplantation, 2021, Vol 36, Issue 7, p1307
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfaa350