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- Title
Experimental evidence of cell dissemination playing a role in pathogenesis of IgA nephropathy in multiple lymphoid organs.
- Authors
Nakata, Junichiro; Suzuki, Yusuke; Suzuki, Hitoshi; Sato, Daisuke; Kano, Tatsuya; Horikoshi, Satoshi; Novak, Jan; Tomino, Yasuhiko
- Abstract
Background Since the pathogenesis of immunoglobulin A (IgA) nephropathy (IgAN) remains unclear, the rationale for current IgAN therapies is still obscure. Recent studies have shown that galactose-deficient IgA1 (GdIgA1) plays a critical role in the pathogenesis of IgAN and can be a non-invasive IgAN biomarker, although the origin of the pathogenic cells producing GdIgA1 is unknown. We examined the cell types and localization of pathogenic cells in IgAN-prone mice. Methods We transplanted bone marrow (BM) or spleen cells with or without specific cell types from IgAN-prone mice, which have many features similar to human IgAN, to identify cell types responsible for the IgAN phenotype and to determine their localization. Results BM transplantation and whole spleen cell transfer from IgAN-prone mice reconstituted IgAN in normal and severe combined immunodeficiency mice. Depletion of CD90+ spleen cells had no affect on reconstitution, whereas CD19+ B cells from the spleen were sufficient to reconstitute IgAN in both recipients. Conclusions These results indicate that CD19+ B cells, which can regulate nephritogenic IgA production in a T-cell-independent manner, are responsible for the disease and are disseminated in peripheral lymphoid organs.
- Subjects
IGA glomerulonephritis; BIOMARKERS; LYMPHATIC diseases; CD90 antigen; SPLEEN; LABORATORY mice
- Publication
Nephrology Dialysis Transplantation, 2013, Vol 28, Issue 2, p320
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfs467