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- Title
Enhanced Anti-Melanogenic Effect of Adlay Bran Fermented with Lactobacillus brevis MJM60390.
- Authors
Nguyen, Huong T.; Gu, Mingkun; Choi, Chun Whan; Choi, Yun-Hyeok; Suh, Joo-Won; Cheng, Jinhua
- Abstract
Fermentation is a traditional technique used to increase nutrients, flavonoids, vitamins, minerals, and the flavor of raw materials. In this study, adlay bran was fermented by Lactobacillus brevis MJM60390 (FAB), and the anti-melanogenic effect was investigated. The results demonstrated that FAB significantly suppressed melanin accumulation in mouse melanogenic B16F10 cells, and the activity was higher than non-fermented adlay bran (NFAB). The molecular mechanism study showed that FAB inhibited melanin synthesis by suppressing the gene expression of melanocortin 1 receptor (Mc1r), melanocyte-inducing transcription factor (Mitf), tyrosinase (Tyr), tyrosinase-related protein-1 (Trp-1), and tyrosinase-related protein-2 (Trp-2) genes. Western blotting analysis showed that FAB strongly decreased the expression of Tyr, Trp-1, and Trp-2 compared to NFAB. Furthermore, phenolic compounds such as gallic acid, p-coumaric acid, ferulic acid, and sinapic acid, which are known for their anti-melanogenic effects, were significantly increased in FAB compared with NFAB. These findings suggest that FAB holds great potential as an anti-melanogenic agent and can be used for the development of whitening cosmetics.
- Subjects
LACTOBACILLUS brevis; FERMENTATION; PHENOL oxidase; FERULIC acid; GALLIC acid
- Publication
Applied Microbiology (2673-8007), 2022, Vol 2, Issue 3, p502
- ISSN
2673-8007
- Publication type
Article
- DOI
10.3390/applmicrobiol2030039