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- Title
Predelivery HbA1c levels and their relationship with adverse perinatal outcomes in women with normal 75-g OGTT.
- Authors
Tang, Xiaoxia; Wei, Jin; Jiang, Zifeng; Wu, Shaohua
- Abstract
Purpose: To analyze the elevation of HbA1c before full-term delivery in single pregnancy with normal 75 g- Oral glucose tolerance test (OGTT) screening and its association with adverse perinatal outcomes. Methods: From January to December 2022, an observational prospective study was conducted in a Single centre in China. 365 single pregnant women with normal OGTT were included in the study. HbA1c was measured during OGTT and before full-term delivery, and perinatal outcomes were collected. Participants' pre-delivery HBA1c values were analyzed and perinatal outcomes were compared. Logistic regression analysis was used for independent risk factors associated with elevated pre-delivery HbA1c ≥ 6.0%. The predictive value and truncation value were analyzed by ROC curve. Results: 15.89% (58/365) of the Participants had a pre-delivery HBA1C value ≥ 6.0%. The incidence of neonatal asphyxia (13.79%, vs. 3.45%, vs. 2.26%, P = 0.007) and amniotic fluid fecal staining (29.31%, vs. 12.64%, vs. 12.03%, P = 0.004) were significantly increased in this group. The independent risk factor associated with pre-delivery HBA1c ≥ 6.0% was the fasting blood glucose(FBG) value of OGTT (OR = 51.308, 95% CI 12.93–203.67, P < 0.01) and the HBA1c value measured during OGTT (OR = 3.608, 95% CI 1.432–9.151, P = 0.007). When FBG was < 4.18 mmol/L and HBA1c was < 5.51%, The accuracy of predicting the pre-delivery HBA1c < 6.0% was 98.2%. Conclusions: 15.89% of the single pregnancy with normal OGTT had HbA1c ≥ 6.0% before full-term delivery, and they had an increased incidence of neonatal asphyxia and amniotic fluid fecal staining. When the FBG ≥ 4.18 mmol/l or the HBA1c ≥ 5.51% during the OGTT screening, repeated OGTT were recommended in late pregnancy.
- Subjects
CHINA; GLYCOSYLATED hemoglobin; GLUCOSE tolerance tests; AMNIOTIC liquid; LOGISTIC regression analysis; BLOOD sugar
- Publication
Archives of Gynecology & Obstetrics, 2024, Vol 310, Issue 1, p293
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-023-07298-w