We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation.
- Authors
Liu, Wangta; Hsu, Yin-Yin; Tang, Jen-Yang; Cheng, Yuan-Bin; Chuang, Ya-Ting; Jeng, Jiiang-Huei; Yen, Chia-Hung; Chang, Hsueh-Wei
- Abstract
Data regarding the effects of crude extract of Commelina plants in oral cancer treatment are scarce. This present study aimed to assess the proliferation-modulating effects of the Commelina sp. (MECO) methanol extract on oral cancer cells in culture, Ca9-22, and CAL 27. MECO suppressed viability to a greater extent in oral cancer cells than in normal cells. MECO also induced more annexin V, apoptosis, and caspase signaling for caspases 3/8/9 in oral cancer cells. The preferential antiproliferation and apoptosis were associated with cellular and mitochondrial oxidative stress in oral cancer cells. Moreover, MECO also preferentially induced DNA damage in oral cancer cells by elevating γH2AX and 8-hydroxyl-2′-deoxyguanosine. The oxidative stress scavengers N-acetylcysteine or MitoTEMPO reverted these preferential antiproliferation mechanisms. It can be concluded that MECO is a natural product with preferential antiproliferation effects and exhibits an oxidative stress-associated mechanism in oral cancer cells.
- Subjects
CANCER cell proliferation; ORAL cancer; CANCER cell culture; PLANT extracts; CANCER cells; ORAL mucosa; DNA damage; CASPASES
- Publication
Antioxidants, 2022, Vol 11, Issue 9, p1813
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11091813