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- Title
Efficient synthesis and antifungal investigation of nucleosides' quaternary ammonium salt derivatives.
- Authors
DMOCHOWSKA, Barbara; PELLOWSKA-JANUSZEK, Lucyna; SAMASZKO-FIERTEK, Justyna; SLUSARZ, Rafal; WAKIEC, Roland; MADAJ, Janusz
- Abstract
Quaternary ammonium salts are a group of compounds with diverse biological properties, the most important of which are their antiviral, antibacterial, and antifungal activities. The quaternization reactions of 5'-O-tosyl derivatives of uridine and thymidine with triethylamine, trimethylamine, 4-(N ,N -dimethylamino)pyridine, 2-methylpyridine, and pyridine are described in this article. Two of the synthesized compounds are exceptional because they are first of this type that demonstrate concentration-dependent antifungal in vitro activity against two species of the genus Candida in minimal YNB-SG medium. The experimental results have been extended by adding full atom molecular dynamics simulations and substrates and products energies evaluation.
- Subjects
ANTIFUNGAL agents; QUATERNARY ammonium salts; ANTIVIRAL agents; MOLECULAR dynamics; NUCLEOSIDE synthesis
- Publication
Turkish Journal of Chemistry, 2019, Vol 43, Issue 1, p157
- ISSN
1300-0527
- Publication type
Article
- DOI
10.3906/kim-1808-34