We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antifungal properties of durancins isolated from Enterococcus durans A5-11 and of its synthetic fragments.
- Authors
Belguesmia, Y.; Choiset, Y.; Rabesona, H.; Baudy‐Floc'h, M.; Le Blay, G.; Haertlé, T.; Chobert, J.‐M.
- Abstract
The aim of this work was to study the antifungal properties of durancins isolated from Enterococcus durans A5-11 and of their chemically synthesized fragments. Enterococcus durans A5-11 is a lactic acid bacteria strain isolated from traditional Mongolian airag cheese. This strain inhibits the growth of several fungi including Fusarium culmorum, Penicillium roqueforti and Debaryomyces hansenii. It produces two bacteriocins: durancin A5-11a and durancin A5-11b, which have similar antimicrobial properties. The whole durancins A5-11a and A5-11b, as well as their N- and C-terminal fragments were synthesized, and their antifungal properties were studied. C-terminal fragments of both durancins showed stronger antifungal activities than other tested peptides. Treatment of D. hansenii LMSA2.11.003 strain with 2 mmol l−1 of the synthetic peptides led to the loss of the membrane integrity and to several changes in the ultra-structure of the yeast cells. Chemically synthesized durancins and their synthetic fragments showed different antimicrobial properties from each other. N-terminal peptides show activities against both bacterial and fungal strains tested. C-terminal peptides have specific activities against tested fungal strain and do not show antibacterial activity. However, the C-terminal fragment enhances the activity of the N-terminal fragment in the whole bacteriocins against bacteria.
- Subjects
ANTIFUNGAL agents; BACTERIOCINS; ENTEROCOCCUS; LACTIC acid bacteria; ANTI-infective agents; DRUG synthesis; FUSARIUM culmorum; PENICILLIUM roqueforti
- Publication
Letters in Applied Microbiology, 2013, Vol 56, Issue 4, p237
- ISSN
0266-8254
- Publication type
Article
- DOI
10.1111/lam.12037