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- Title
Gamma-Butyrolactone Overdose Potentially Complicated by Co-Ingestion of Industrial Solvent N-Methyl-2-Pyrrolidone.
- Authors
Melamed, Jonathan; Gerona, Roy; Blanc, Paul D; Takamoto, Paul; Conner, Stephanie; Goodnough, Robert
- Abstract
Gamma-hydroxybutyrate (GHB) is misused as an intoxicant, either alone or concurrently with other substances. Because GHB is illegal, the precursor chemicals 1,4-butanediol and gamma-butyrolactone are also misused for the same effect, either through pre-ingestion alteration or endogenous metabolism to GHB. We describe a case of a 50-year-old man with a history of polysubstance misuse who experienced an overdose of GHB from gamma-butyrolactone ingestion. The patient also co-ingested a common industrial solvent, N-methyl-2-pyrrolidone (NMP). This co-ingested substance raised theoretical concern of metabolism to a GHB congener, underscoring that the emergence of new psychoactive substance use patterns requires ongoing vigilance and toxicologic confirmation.
- Subjects
BUTYROLACTONES; GAMMA-hydroxybutyrate; SUBSTANCE abuse; CHEMICAL precursors; SOLVENTS; BUTANEDIOL
- Publication
Journal of Analytical Toxicology, 2021, Vol 45, Issue 3, p322
- ISSN
0146-4760
- Publication type
Article
- DOI
10.1093/jat/bkaa076