We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prognostic and Therapeutic Relevance of Molecular Subtypes in High-Grade Serous Ovarian Cancer.
- Authors
Konecny, Gottfried E.; Wang, Chen; Hamidi, Habib; Winterhoff, Boris; Kalli, Kimberly R.; Dering, Judy; Ginther, Charles; Chen, Hsiao-Wang; Dowdy, Sean; Cliby, William; Gostout, Bobbie; Podratz, Karl C.; Keeney, Gary; Wang, He-Jing; Hartmann, Lynn C.; Slamon, Dennis J.; Goode, Ellen L.
- Abstract
Molecular classification of high-grade serous ovarian cancer (HGSOC) using transcriptional profiling has proven to be complex and difficult to validate across studies. We determined gene expression profiles of 174 well-annotated HGSOCs and demonstrate prognostic significance of the prespecified TCGA Network gene signatures. Furthermore, we confirm the presence of four HGSOC transcriptional subtypes using a de novo classification. Survival differed statistically significantly between de novo subtypes (log rank, P = .006) and was the best for the immunoreactive-like subtype, but statistically significantly worse for the proliferative- or mesenchymal-like subtypes (adjusted hazard ratio = 1.89, 95% confidence interval = 1.18 to 3.02, P = .008, and adjusted hazard ratio = 2.45, 95% confidence interval = 1.43 to 4.18, P = .001, respectively). More prognostic information was provided by the de novo than the TCGA classification (Likelihood Ratio tests, P = .003 and P = .04, respectively). All statistical tests were two-sided. These findings were replicated in an external data set of 185 HGSOCs and confirm the presence of four prognostically relevant molecular subtypes that have the potential to guide therapy decisions.
- Subjects
OVARIAN cancer; PROGNOSIS; THERAPEUTICS; GENE expression; MOLECULAR genetics
- Publication
JNCI: Journal of the National Cancer Institute, 2014, Vol 106, Issue 10, p1
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/dju249