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- Title
Prostate Health Index v porovnání s biopsií a pooperační histologií v predikci karcinomu prostaty.
- Authors
P., Brož; O., Dolejšová; R., Fuchsová; O., Topolčan; J., Racek; H., Sedláčková; O., Hes; V., Eret; L., Pecen; M., Hora; R., Kučera
- Abstract
Aim: To assess the Prostate Health Index (PHI) as a marker of tumor aggressiveness in comparison with prostate biopsy and postoperative histology. Methods: Our cohort consisted of 474 patients indicated for radical prostatectomy with preoperative measurements of total prostate-specific antigen, free prostate-specific antigen, [-2]proPSA, calculated %freePSA, and PHI. The Gleason score was determined during biopsy and after radical prostatectomy. Using the Gleason score, we divided the group of patients into the 2 subgroups: Gleason score 6 and Gleason score =7. This division was performed according to the biopsy Gleason score and according to the postoperative Gleason score. We compared total prostate specific antigen, [-2]proPSA, %freePSA, and PHI in the subgroups Gleason score 6 and Gleason score =7 after biopsy and the definitive score. Results: Of the calculated biopsy, Gleason score 6 and Gleason score =7 subgroups, [-2]proPSA, PHI and PSA (p < 0.0001, p < 0.0001 and p = 0.0012) were statistically significant. In case of %freePSA statistically significant differences were not present (p = 0.9306). Of the definitive Gleason score 6 and Gleason score =7 subgroups, PHI, [-2]proPSA, %freePSA, and PSA (p < 0.0001, p < 0.0001, p < 0.0001, and p = 0.0012) were statistically significant. The best area under the curve value (0.7649) was achieved by PHI when the subgroups were established according to the postoperative Gleason score. Conclusion: PHI is the best of tested markers for the categorization of Gleason score 6 and Gleason score =7 tumors. Implementation of PHI can be useful in the management of patients with prostate cancer. PHI can be a helpful marker for indication of active surveillance or radical prostatectomy, or simplify the decision of whether to perform nerve-sparing radical prostatectomy.
- Publication
Klinická Biochemie a Metabolismus, 2019, Vol 27, Issue 1, p9
- ISSN
1210-7921
- Publication type
Article