We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Methods for Osteoarthritis Animal Models.
- Authors
Phetsangouane, S.; LI Yan-lin; JIA Di
- Abstract
Osteoarthritis (OA) is the most common joint disease.Millions of people suffer from this musculoskeletal degenerative disorder.Osteoarthritis is refractory to treatment and it often leads to disability,deterioration of the quality of life and a heavy economic impact on every nation’s health systems.Investigating the disease directly on humans may be challenging.The aim of the present study is to investigate the advantages of the methods currently used in OA research.The methods are divided into induced models and induced models are further subdivided into surgical and chemical models according to the procedure used to induce OA.Surgical induction of OA is the most commonly used procedure,which alters the exerted strain on the joint and/or alters load bearing leading to instability of the joint and induction of OA.Chemical models are generated by intra-articular injection of modifying factors or by systemically administering noxious agents,such as quinolones.Overall,there is no single method that is ideal for studying degenerative OA.However,in the present review,an attempt is made to clarify the most appropriate use of each method for OA animal model.
- Subjects
OSTEOARTHRITIS; CARTILAGE; ANIMAL models in research
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2018, Vol 39, Issue 1, p24
- ISSN
2095-610X
- Publication type
Article