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- Title
High-throughput Screening of Mouse Knockout Lines Identifies True Lean and Obese Phenotypes.
- Authors
Brommage, Robert; Desai, Urvi; Revelli, Jean-Pierre; Donoviel, Dorit B.; Fontenot, Gregory K.; DaCosta, Christopher M.; Smith, Deon D.; Kirkpatrick, Laura L.; Coker, Kenneth J.; Donoviel, Michael S.; Eberhart, Derek E.; Holt, Kathleen H.; Kelly, Michael R.; Paradee, William J.; Philips, Anne V.; Platt, Kenneth A.; Suwanichkul, Adisak; Hansen, Gwenn M.; Sands, Arthur T.; Zambrowicz, Brian P.
- Abstract
The article deals with a study which conceptualized a high-throughput approach to knockout (KO) and phenotype mouse orthologs of the 5,000 potential drug targets in the human genome. A brief review of the related literature on mouse KO technology is offered. The body-fat stores in eight KO and four wild-type (WT) littermate chow-fed mice from each line were estimated using dual-energy X-ray absorptiometry (DXA). A detailed discussion of the study findings is presented.
- Subjects
HUMAN genome; GENOTYPE-environment interaction; DOSAGE forms of drugs; DRUG target; GENETICS
- Publication
Obesity (19307381), 2008, Vol 16, Issue 10, p2362
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1038/oby.2008.361