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- Title
review of machine learning approaches for drug synergy prediction in cancer.
- Authors
Torkamannia, Anna; Omidi, Yadollah; Ferdousi, Reza
- Abstract
Combinational pharmacotherapy with the synergistic/additive effect is a powerful treatment strategy for complex diseases such as malignancies. Identifying synergistic combinations with various compounds and structures requires testing a large number of compound combinations. However, in practice, examining different compounds by in vivo and in vitro approaches is costly, infeasible and challenging. In the last decades, significant success has been achieved by expanding computational methods in different pharmacological and bioinformatics domains. As promising tools, computational approaches such as machine learning algorithms (MLAs) are used for prioritizing combinational pharmacotherapies. This review aims to provide the models developed to predict synergistic drug combinations in cancer by MLAs with various information, including gene expression, protein–protein interactions, metabolite interactions, pathways and pharmaceutical information such as chemical structure, molecular descriptor and drug–target interactions.
- Subjects
DRUG synergism; PROTEIN-protein interactions; MACHINE learning; CHEMICAL structure; GENE expression; DRUG therapy
- Publication
Briefings in Bioinformatics, 2022, Vol 23, Issue 3, p1
- ISSN
1467-5463
- Publication type
Article
- DOI
10.1093/bib/bbac075