We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis.
- Authors
Yuhua Tian; Xianghui Ma; Cong Lv; Xiaole Sheng; Xiang Li; Ran Zhao; Yongli Song; Andl, Thomas; Plikus, Maksim V.; Jinyue Sun; Fazheng Ren; Jianwei Shuai; Lengner, Christopher J.; Wei Cui; Zhengquan Yu
- Abstract
Intestinal regeneration and tumorigenesis are believed to be driven by intestinal stem cells (ISCs). Elucidating mechanisms underlying ISC activation during regeneration and tumorigenesis can help uncover the underlying principles of intestinal homeostasis and disease including colorectal cancer. Here we show that miR-31 drives ISC proliferation, and protects ISCs against apoptosis, both during homeostasis and regeneration in response to ionizing radiation injury. Furthermore, miR-31 has oncogenic properties, promoting intestinal tumorigenesis. Mechanistically, miR-31 acts to balance input from Wnt, BMP, TGFβ signals to coordinate control of intestinal homeostasis, regeneration and tumorigenesis. We further find that miR-31 is regulated by the STAT3 signaling pathway in response to radiation injury. These findings identify miR-31 as a critical modulator of ISC biology, and a potential therapeutic target for a broad range of intestinal regenerative disorders and cancers.
- Subjects
STEM cells; APOPTOSIS; HOMEOSTASIS; INTESTINAL diseases; NEOPLASTIC cell transformation; REGENERATION (Biology)
- Publication
eLife, 2017, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.29538