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- Title
Bias mĕření základních analytů krevního séra. Výsledky a interpretace soudobých studií.
- Authors
Friedecký, B.; Kratochvíla, J.
- Abstract
Objective: Comment of bias values reached in recent results of four commutable reference materials and programs in general blood serum analytes and their comparison with results of EQA program SEKK-AKS in 2012-2014. Methods: As commutable reference materials were used sets of individual blood donors and non spiked and spiked frozen native serum pools. Bias values were calculated as differences of manufacturer groups means from robust mean of all participants. In some cases were used values obtained by reference methods. Results, discussion: Majority of bias values did not exceeded 4 %. No significant dependency on the on the kind of matrix was observed. Some large bias values were observed only exceptionally in some methods of uric acid and phosphate. Measurement of albumin was influenced by differences between BCG and BCP methods, higher concentration of triglycerides is reason of large bias in HDL and LDL method. Commonly are bias values higher than requested, from biological variations derived. No significant matrix influence on the bias value was observed in measurement of general blood serum analyzed. We think that ex post commutability evaluation of EQA program results based on the use standard lyophilized materials can be realized by assessment relation of bias to uncertainty of reference values. There is necessary to prefer reference method values or robust mean values as criterion not only for proficiency of participants and also for monitoring of level in standardization.
- Publication
Klinická Biochemie a Metabolismus, 2015, Vol 23, Issue 3, p105
- ISSN
1210-7921
- Publication type
Article