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- Title
Expression of TRPM8 in human reactive lymphoid tissues and mature B-cell neoplasms.
- Authors
Hirai, Akinori; Aung, Naing Ye; Ohe, Rintaro; Nishida, Akiko; Kato, Tomoya; Meng, Hongxue; Ishizawa, Kenichi; Fujii, Junichi; Yamakawa, Mitsunori
- Abstract
Transient receptor potential melastatin 8 (TRPM8) is a member of the transient receptor potential superfamily of Ca2+ channels. The aim of the present study was to clarify TRPM8 expression in reactive lymphoid tissues and mature B-cell neoplasms. Reactive and neoplastic lymphoid tissues were used to evaluate TRPM8 expression by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). TRPM8+ cells were frequently detected in the follicular light zone and marginal zone of reactive lymphoid tissues. Double immunostaining revealed that TRPM8+ cells co-expressed cluster of differentiation (CD) 38, CD79a, CD138, interferon regulatory factor 4/melanoma associated antigen (mutated) 1, B cell CLL/lymphoma 6 and transmembrane activator and CAML interactor. TRPM8+ neoplastic cells were frequently detected in plasma cell myeloma. The positive band of TRPM8 mRNA was confirmed by RT-PCR in cases of myeloma. The present study is, to the best of our knowledge, the first to demonstrate the expression of TRPM8 in reactive lymphoid tissues and mature B-cell neoplasms, revealing that TRPM8 is frequently expressed in pre-plasmablasts, plasmablasts, plasma cells and mature B-cell lymphomas that are likely to differentiate into plasma cells.
- Subjects
IMMUNOHISTOCHEMISTRY; LYMPHOID tissue; B cell lymphoma; INTERFERON regulatory factors; MESSENGER RNA
- Publication
Oncology Letters, 2018, Vol 16, Issue 5, p5930
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2018.9386