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- Title
Ru(terpy)-Based Conducting Polymer in Electrochemical Biosensing of Epinephrine.
- Authors
Meloni, Francesca; Pilo, Maria I.; Sanna, Gavino; Spano, Nadia; Zucca, Antonio; Huang, Chih-Ching
- Abstract
Featured Application: Ru(terpy)-based conducting polymers can be used as modifying agents in enzyme-based am-perometric biosensors to significantly enhance selectivity and sensitivity thanks to the effi-cient electron-transfer process promoted by the simultaneous presence of the organic con-ducting framework and the metal center. A heteroleptic [Ru(terpy)2]2+ (terpy = 2,2′:6′,2″-terpyridine) complex was electrochemically polymerized to give the corresponding metal-containing conducting polymer on gold and glassy carbon electrodes. The polymerization of the Ru(II) complex was allowed by a terthiophene functionalization on one of the two terpy coordinating fragments, whereas the presence of -COOH substituents on the second terpy ligand enabled the film to immobilize a tyrosinase enzyme by cross-linking with glutaraldehyde. Then, the Ru(terpy) conducting polymer worked as a transducer as well as an immobilizing agent in the design of amperometric biosensors for the determination of epinephrine. The electrochemical behavior of enzymatic sensors containing Ru(terpy)-based conducting polymers was investigated by differential pulse voltammetry and chronoamperometry. Analytical performances and kinetic parameters were calculated, suggesting a potential application of the reported biosensors in the determination of epinephrine in pharmaceutical products.
- Subjects
CONDUCTING polymers; RUTHENIUM compounds; ADRENALINE; CARBON electrodes; METAL-organic frameworks; GLUTARALDEHYDE; RUTHENIUM catalysts; ALPHA-terthienyl
- Publication
Applied Sciences (2076-3417), 2021, Vol 11, Issue 5, p2065
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app11052065