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- Title
Prognostic significance of Dicer expression in hepatocellular carcinoma.
- Authors
LI ZHANG; CUIJU WANG; SHUFENG LIU; YUFEI ZHAO; CHAO LIU; ZHANJUN GUO
- Abstract
Dicer is a RNaseIII endonuclease of the microRNA processing pathway, which is implicated in carcinogenesis of various types of human cancer. The present study assessed the expression level of Dicer in hepatocellular carcinoma (HCC) tissue to evaluate its association with HCC tumorigenesis. A low expression of Dicer was significantly associated with a shorter postoperative survival time of patients with HCC, which was assessed using the log-rank test with Kaplan-Meier survival analysis. Multivariate analysis identified that Dicer expression was an independent predictor for HCC outcome (relative risk, 0.660; 95% confidence interval, 0.506-0.861; P=0.002). A functional assay demonstrated that Dicer overexpression inhibited the proliferation and promoted the apoptosis of HCC cells. In addition, a Transwell assay revealed that Dicer markedly inhibited the migration and invasion of HCC cells. The present findings indicate that Dicer expression modified the outcomes of HCC patients by inhibiting proliferation, promoting apoptosis and inhibiting metastasis of HCC cells.
- Subjects
LIVER cancer; RIBONUCLEASE III; MICRORNA; APOPTOSIS; GENE expression; INHIBITION of cellular proliferation; IMMUNOHISTOCHEMISTRY; CELL migration; PROGNOSIS
- Publication
Oncology Letters, 2016, Vol 11, Issue 6, p3961
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2016.4547