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- Title
Lymph node metastasis‐dependent molecular classification in papillary thyroid carcinoma defines aggressive metastatic outgrowth.
- Authors
Seo, Dong Hyun; Lee, Seul Gi; Lee, Hwa Young; Jeong, Seonhyang; Park, Sunmi; Lee, Jandee; Jo, Young Suk
- Abstract
For discovery, we ran differential gene expression analysis based on the negative binomial distribution (DESEQ2) for 97 patients without LNM [LNM (-)] and 195 patients with LNM [LNM (+)] from our PTC patient cohort (Table S1). (A) Results of ssGSEA analysis for GSE60542 paired primary tumour and LNM samples and GSE151179 primary tumour and LNM samples were figured into a heatmap. Lymph node metastasis (LNM) is the most important prognostic factor and a crucial indicator in the development of treatment strategies for patients with papillary thyroid carcinoma (PTC).[[1]] A vast majority (25%-60%) of patients with PTC undergo thyroidectomy with neck node dissection.[3] However, researchers continue to debate whether LNM is leading to over-treatment of patients with PTC.[[1], [4]] Interestingly, we have noted that upon stratifying LNM risk in PTC and clinical outcomes according to distinct molecular characteristics, LNM showing enrichment of genes related to inflammation and epithelial-mesenchymal transition (EMT) were more aggressive than metabolically adapted LNM, and this was applicable in other tumours. Lymph node metastasis-dependent molecular classification in papillary thyroid carcinoma defines aggressive metastatic outgrowth.
- Subjects
THYROID cancer; FISHER exact test; PAPILLARY carcinoma; PROGRESSION-free survival; LYMPH nodes; GENE expression
- Publication
Clinical & Translational Medicine, 2023, Vol 13, Issue 3, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1211