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- Title
Striatal dopamine transporter availability with [<sup>123</sup>I]β-CIT SPECT is unrelated to gender or menstrual cycle.
- Authors
Best, Susan E.; Sarrel, Philip M.; Malison, Robert T.; Laruelle, Marc; Zoghbi, Sami S.; Baldwin, Ronald M.; Seibyl, John P.; Innis, Robert B.; Van Dyck, Christopher H.
- Abstract
Objectives: The effect of gender and female menstrual cycle on human striatal dopamine transporters (DATs) was investigated with single-photon emission computed tomography (SPECT) using the ligand 2β-carbomethoxy-3β-(4-[123I]iodophenyl)tropane. Methods: Ten female subjects aged 18-40 years (25.3±7.3 years) were scanned twice during the early follicular and the mid-luteal phases to detect any hormone-mediated changes in DAT availability in the striatum or serotonin transporter (SERT) availability in brainstem-diencephalon. Plasma estradiol and progesterone levels were obtained at the time of SPECT and confirmed the expected increases from the follicular to the luteal phases. Finally, in a post hoc analysis of a previously published healthy-subject sample, striatal DAT availability was compared between 70 male and 52 female subjects who ranged in age from 18 to 88 years. Results: In the ten menstrual cycle subjects, DAT availability (V3″) in striatum and SERT availability in brainstem-diencephalon did not differ between follicular and luteal phases. Moreover, change in V3″ for striatum or brainstem-diencephalon was uncorrelated with change in plasma estradiol or progesterone from the follicular to the luteal phase. In the larger healthy-subject sample, there was no significant effect of gender or the interaction of age and gender on striatal V3″. Conclusions: These findings suggest that in using DAT or SERT ligands in the study of neuropsychiatric disorders, matching of female subjects according to a menstrual cycle phase is unnecessary. Although the present investigation did not confirm previous reports of gender differences in striatal DAT availability, controlling for gender in such studies still seems advisable.
- Subjects
DOPAMINE; PHOTON emission; MENSTRUAL cycle; SEX differences (Biology); NEUROPSYCHIATRY; ENDOCRINE gynecology
- Publication
Psychopharmacology, 2005, Vol 183, Issue 2, p181
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s00213-005-0158-5