We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents.
- Authors
Isaksson, Johan; Grigorenko, Elena; Oreland, Lars; af Klinteberg, Britt; Koposov, Roman; Ruchkin, Vladislav
- Abstract
Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia ( n = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania.
- Subjects
PATHOLOGICAL psychology; MENTAL health of juvenile offenders; CONDUCT disorders in children; DOPAMINE hydroxylase; GENETIC polymorphisms; LOCUS (Genetics)
- Publication
European Archives of Psychiatry & Clinical Neuroscience, 2016, Vol 266, Issue 8, p771
- ISSN
0940-1334
- Publication type
Article
- DOI
10.1007/s00406-015-0664-3