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- Title
Meningococcal disease associated with an acute post-streptococcal complement deficiency.
- Authors
Daskas, Nikolaos; Farmer, Katie; Coward, Richard; Erlewyn-Lajeunesse, Michel
- Abstract
Chronic deficiencies in the complement pathway proteins are associated with an increased risk of meningococcal disease. Such deficiencies are caused by primary congenital immunodeficiency of a complement protein, properdin or mannose binding lectin, or are secondary to consumption of complement by systemic lupus erythematosus (SLE) or membranoproliferative glomerulonephritis (MPGN). Whatever the cause, the complement deficiency is always chronic. Here we report a case of meningococcal disease (MCD) in a child with a transient complement deficiency (CD), caused by post-streptococcal glomerulonephritis (PSGN).
- Subjects
CHRONIC diseases; AUTOIMMUNE diseases; VASCULAR diseases; JUVENILE diseases; PEDIATRIC nephrology; INTERNAL medicine; NEPHROLOGY
- Publication
Pediatric Nephrology, 2007, Vol 22, Issue 5, p747
- ISSN
0931-041X
- Publication type
Report
- DOI
10.1007/s00467-006-0394-x