We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer.
- Authors
Kong, W; He, L; Richards, E J; Challa, S; Xu, C-X; Permuth-Wey, J; Lancaster, J M; Coppola, D; Sellers, T A; Djeu, J Y; Cheng, J Q
- Abstract
MicroRNA-155 (miR-155) is frequently upregulated in various types of human cancer; however, its role in cancer angiogenesis remains unknown. Here, we demonstrate the role of miR-155 in angiogenesis through targeting von Hippel-Lindau (VHL) tumour suppressor in breast cancer. Ectopic expression of miR-155 induced whereas knockdown of miR-155 inhibited human umbilical vein endothelial cell network formation, proliferation, invasion and migration. Furthermore, mammary fat pad xenotransplantation of ectopically expressed miR-155 resulted in extensive angiogenesis, proliferation, tumour necrosis and recruitment of pro-inflammatory cells such as tumour-associated macrophages. Expression of VHL abrogated these miR-155 effects. Moreover, miR-155 expression inversely correlates with VHL expression level and is associated with late-stage, lymph node metastasis and poor prognosis, as well as triple-negative tumour in breast cancer. These findings indicate that miR-155 has a pivotal role in tumour angiogenesis by downregulation of VHL, and provide a basis for miR-155-expressing tumours to embody an aggressive malignant phenotype, and therefore miR-155 is an important therapeutic target in breast cancer.
- Subjects
MICRORNA; BREAST cancer prognosis; NEOVASCULARIZATION; ENDOTHELIAL cells; MACROPHAGES; CANCER cell proliferation; CANCER invasiveness
- Publication
Oncogene, 2014, Vol 33, Issue 6, p679
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/onc.2012.636