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- Title
EBER-1 positive diffuse large cell lymphoma presenting as lupus nephritis.
- Authors
Lin, Ming-Hsien; Huang, Jeng-Jong; Chen, Tsai-Yun; Chen, Fen-Fen; Chang, Kong-Chao; Liu, Ming-Fei; Huang, Wen-Tsung; Su, Wu-Chou; Tsao, Chao-Jung
- Abstract
Approximately one-third of membranous glomerulonephritis (MGN) cases in adults are associated with systemic diseases, including systemic lupus erythematosus (SLE) or malignancies. Malignancyassociated glomerulonephritis is rarely found in non-Hodgkin's lymphoma (NHL). Epstein-Barr virus (EBV) has been postulated to contribute to the pathogenesis of both SLE and NHL. We described a 37-year-old woman with nephrotic syndrome who presented with clinical features of SLE and renal-biopsy revealed lupus MGN. The patient also suffered from concomitant progressive lymphadenopathy and NHL (diffuse large B-cell type) was demonstrated by neck lymph node biopsy. Serologic studies demonstrated EBV infection and specific EBVantigens were present on lymph node and metastatic sites. We offer a discussion regarding the complex relationships between SLE, NHL, MGN and EBV. Lupus (2003) 12, 486-489.
- Subjects
LUPUS erythematosus; LYMPHOMAS; EPSTEIN-Barr virus
- Publication
Lupus, 2003, Vol 12, Issue 6, p486
- ISSN
0961-2033
- Publication type
Article
- DOI
10.1191/0961203303lu414cr