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- Title
Serial exome analysis of disease progression in premalignant gammopathies.
- Authors
Zhao, S; Choi, M; Heuck, C; Mane, S; Barlogie, B; Lifton, R P; Dhodapkar, M V
- Abstract
The article discusses the study on the serial exome analysis of disease progression in premalignant gammopathies. It notes the multiple myeloma (MM) characterized by progressive growth of malignant plasma cells where nearly all cases are preceded by asymptomatic monoclonal gammopathies (AMGs). The study involves whole-exome sequencing on tumor and germline DNA from 10 patients. It mentions that four of the patients progressed to clinical MM requiring therapy.
- Subjects
MONOCLONAL gammopathies; MULTIPLE myeloma; PLASMA cell diseases; NUCLEOTIDE sequence; DNA
- Publication
Leukemia (08876924), 2014, Vol 28, Issue 7, p1548
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/leu.2014.59