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- Title
Pharmacokinetics and safety of a 270 mcg kg<sup>−1</sup> dose of room temperature stable recombinant activated factor VII in patients with haemophilia.
- Authors
MORFINI, M.; BJERRE, J.
- Abstract
Summary. Recombinant factor VIIa (rFVIIa), a haemostatic bypassing agent, has been shown to be effective and well-tolerated in patients with haemophilia at standard doses of 90 and 270 mcg kg−1. A new room temperature stable formulation of rFVIIa was recently developed that was shown to be bioequivalent to and maintain the safety and efficacy profiles of the original formulation at a dose of 90 mcg kg−1. The aim of this study was to examine the pharmacokinetics and safety of rFVIIa-RT at a 270 mcg kg−1 dose. The pharmacokinetics and safety of a 270 mcg kg−1 dose of the newly formulated room-temperature stable recombinant activated factor VII (BHK-rFVIIa-RT) was evaluated in 23 subjects with congenital haemophilia A or B. The pharmacokinetic profile for the 270 mcg kg−1 dose of BHK-rFVIIa-RT was in line with what was previously observed for the 90 mcg kg−1 dose. The AUClast and Cmax of BHK-rFVIIa-RT at 270 mcg kg−1 (346.65 h IU mL−1 and 146.12 IU mL−1 respectively) were proportionally higher than those observed at the lower 90 mcg kg−1 dose of BHK-rFVIIa-RT (113.26 h IU mL−1 and 52.83 IU mL−1) demonstrating the dose-dependent nature of BHK-rFVIIa-RT activity. There were no thromboembolic events or related serious adverse events reported with the increased dose of BHK-rFVIIa-RT, and no patients withdrew because of adverse events. This indicates that BHK-rFVIIa-RT was well tolerated at a higher dosage and maintains the favourable safety profile established by rFVIIa. Therefore, the 270 mcg kg−1 dose of BHK-rFVIIa-RT shows dose-dependent pharmacokinetic effects that do not appear to increase the risk of serious adverse events.
- Subjects
PHARMACOKINETICS; HEMOPHILIA; PATIENTS; DRUGS; RECOMBINANT microorganisms
- Publication
Haemophilia, 2011, Vol 17, Issue 6, p860
- ISSN
1351-8216
- Publication type
Article
- DOI
10.1111/j.1365-2516.2011.02498.x