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- Title
NONSUNLIGHT RISK FACTORS FOR MALIGNANT MELANOMA PART II: IMMUNITY, GENETICS, AND WORKPLACE PREVENTION.
- Authors
Rockley, Paul F.; Trieff, Norman; Wagner Jr., Richard F.; Tyring, Stephen K.
- Abstract
The article presents information on nonsunlight risk factors for malignant melanoma. The article discusses occupational and environmental exposure to a variety of chemical agents and physical conditions. It also focuses on host factors for malignant melanoma such as immunity and genetic risk. In addition, strategies toward the prevention of workplace malignant melanoma are presented. Both clinical and in vitro studies suggest a role for immune surveillance in the development of malignant melanoma. Immune surveillance, according to the hypothesis, is the mechanism by which the immune system monitors somatic tissues for evidence of malignantly transformed cells. When somatic cells with neoantigeneic determinants are identified and processed, Langerhans cells and T lymphocytes become activated and may eliminate the cells before a clinically detectable tumor emerges.
- Subjects
MELANOMA; CANCER risk factors; WORK environment; IMMUNE system; LANGERHANS cells; NEUROENDOCRINE tumors; DENDRITIC cells; LEUCOCYTES
- Publication
International Journal of Dermatology, 1994, Vol 33, Issue 7, p462
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/j.1365-4362.1994.tb02854.x