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- Title
Impact of Pdx1-associated chromatin modifiers on islet β-cells.
- Authors
Spaeth, J. M.; Walker, E. M.; Stein, R.
- Abstract
Diabetes mellitus arises from insufficient insulin secretion from pancreatic islet β-cells. In type 2 diabetes ( T2D), β-cell dysfunction is associated with inactivation and/or loss of transcription factor (TF) activity, including Pdx1. Notably, this particular TF is viewed as a master regulator of pancreas development and islet β-cell formation, identity and function. TFs, like Pdx1, recruit coregulators to transduce activating and/or repressing signals to the general transcriptional machinery for controlling gene expression, including modifiers of DNA, histones and nucleosome architecture. These coregulators impart a secondary layer of control that can be exploited to modulate TF activity. In this review, we describe Pdx1-recruited coregulators that impact chromatin structure, consequently influencing normal β-cell function and likely Pdx1 activity in pathophysiological settings.
- Subjects
TYPE 2 diabetes; PANCREATIC beta cells; ISLET cell tumor; TRANSCRIPTION factors; CELL physiology; PATHOLOGICAL physiology
- Publication
Diabetes, Obesity & Metabolism, 2016, Vol 18, p123
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.12730