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- Title
Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting ɛ germline transcription induced by STAT6 activation.
- Authors
Kim, Yoon Hee; Yoshimoto, Miki; Nakayama, Kazuko; Tanino, Sousuke; Fujimura, Yoshinori; Yamada, Koji; Tachibana, Hirofumi
- Abstract
Abstract: Interleukin (IL)-4 is a critical stimulator that induces ɛ germline transcripts (ɛGT) for switch recombination to initiate immunoglobulin (Ig) E and is important in allergic disease pathogenesis. We found pentagalloylglucose (PGG) inhibited IL-4-induced ɛGT expression. PGG exerted its inhibitory function by suppressing IL-4-induced activation of IL-4Rα, JAK3 and STAT6. Furthermore, tannic acid, a higher galloylated PGG, attenuated ovalbumin-induced IgE production in vivo by inhibiting IL-4-induced ɛGT expression and the IL-4 signaling pathway. In conclusion, our results suggest that tannic acid may attenuate allergic diseases by suppressing IgE production by inhibiting IL-4-induced signaling.
- Subjects
TANNINS; PENTAGALLOYLGLUCOSE; IMMUNOGLOBULIN E; GERM cells; GENETIC transcription; INTERLEUKIN-4; ALLERGIES
- Publication
FEBS Open Bio, 2013, Vol 3, p341
- ISSN
2211-5463
- Publication type
Article
- DOI
10.1016/j.fob.2013.07.008