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- Title
EFECTO DEL CAMBIO DE LA TERAPIA ANTIRRETROVIRAL EN LA FALLA VIROLÓGICA EN UNA COHORTE DE PACIENTES QUE CONVIVEN CON EL VIH EN MEDELLÍN, ANTIOQUIA, COLOMBIA.
- Authors
GÓMEZ HERNÁNDEZ, ANDREA JULIANA; MEDINA VÁSQUEZ, LINA MARÍA; MOLINA CASTAÑO, CARLOS FEDERICO; BOTERO GARCÉS, JORGE HUMBERTO; ALZATE ÁNGEL, JUAN CARLOS
- Abstract
Objective: to determine the effect of the change in antiretroviral therapy on virological control in a cohort of HIV positive patients corresponding to a healthcare institution in Medellín, Antioquia (Colombia) in 2017. Materials and methods: cross-sectional, comparative analytical observational study. It was performed in a cohort of 1245 patients living with HIV. Results: a total of 322 patients were evaluated. The main reason for change was the presence of adverse effects to antiretroviral therapy, followed by virological failure without genotype and antiretroviral therapy intolerance. Virological failure, PR 1.4 95% CI (1.2-1.6, p 0,00), having genotype, PR 1.2 95% CI (1.1-1.3, p 0,00) and suffering from an opportunistic infection, PR 1.3 95% CI (1.0-1.6, p 0,03), were associated with a greater number of changes to antiretroviral therapy. Adherence to antiretroviral therapy, PR 0.18 95% CI (0.1-0.3, p 0,00) and taking other non-HIV-related medications (PR 0.6, 95% CI 0.4-0, 8, p 0,005) were associated with a lower frequency of change of antiretroviral therapy. The change in antiretroviral therapy (adjusted OR 3.4, 95% CI (2.0-5.8)) remains the most important prognostic factor for virological failure. Conclusion: the change in antirretroviral therapy, defined in this study as the main exposure variable, represents the main risk factor for virological failure, even when was adjusted for other variables.
- Publication
Archivos de Medicina (1657-320X), 2020, Vol 20, Issue 2, p269
- ISSN
1657-320X
- Publication type
Article
- DOI
10.30554/archmed.20.2.3490.