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CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1<sup>G93A</sup> mice with a C57BL/6 background.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-98317-w
By:
- Lum, Jeremy S.;
- Brown, Mikayla L.;
- Farrawell, Natalie E.;
- McAlary, Luke;
- Ly, Diane;
- Chisholm, Christen G.;
- Snow, Josh;
- Vine, Kara L.;
- Karl, Tim;
- Kreilaus, Fabian;
- McInnes, Lachlan E.;
- Nikseresht, Sara;
- Donnelly, Paul S.;
- Crouch, Peter J.;
- Yerbury, Justin J.
Publication type:
Article
Cerebrovascular amyloid angiopathy in bioengineered vessels is reduced by high‐density lipoprotein particles enriched in apolipoprotein E: Development of new models and analysis methods/amyloid/Abeta.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043473
By:
- Robert, Jerome;
- Button, Emily B.;
- Martin, Emma;
- McAlary, Luke;
- Gidden, Zoe;
- Gilmore, Megan;
- Boyce, Guilaine K.;
- Caffrey, Tara M.;
- Agbay, Andrew;
- Clark, Amanda;
- Silverman, Judith M;
- Cashman, Neil R.;
- Wellington, Cheryl L.
Publication type:
Article
P4‐163: THE PATHOLOGICAL INTERACTOME OF TDP‐43 INCLUDES HUMAN WILDTYPE SOD1.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1336, doi. 10.1016/j.jalz.2019.06.3825
By:
- Pokrishevsky, Edward;
- DuVal, Michele;
- McAlary, Luke;
- Zhao, Beibei;
- Gibbs, Ebrima;
- Louadi, Sarah;
- Kaplan, Johanne;
- Plotkin, Steven S.;
- Allison, W. Ted;
- Cashman, Neil R.
Publication type:
Article
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins.
Published in:
Glia, 2020, v. 68, n. 2, p. 407, doi. 10.1002/glia.23728
By:
- Deora, Vandana;
- Lee, John D.;
- Albornoz, Eduardo A.;
- McAlary, Luke;
- Jagaraj, Cyril J.;
- Robertson, Avril A. B.;
- Atkin, Julie D.;
- Cooper, Matthew A.;
- Schroder, Kate;
- Yerbury, Justin J.;
- Gordon, Richard;
- Woodruff, Trent M.
Publication type:
Article
Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis.
Published in:
Frontiers in Molecular Neuroscience, 2019, p. 1, doi. 10.3389/fnmol.2019.00262
By:
- McAlary, Luke;
- Plotkin, Steven S.;
- Yerbury, Justin J.;
- Cashman, Neil R.
Publication type:
Article
High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS).
Published in:
Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-64366-0
By:
- Lambert-Smith, Isabella A.;
- Shephard, Victoria K.;
- McAlary, Luke;
- Yerbury, Justin J.;
- Saunders, Darren N.
Publication type:
Article
Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases.
Published in:
2019
By:
- McAlary, Luke;
- Plotkin, Steven S.;
- Cashman, Neil R.
Publication type:
journal article
Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.
Published in:
PLoS Biology, 2024, v. 22, n. 1, p. 1, doi. 10.1371/journal.pbio.3002462
By:
- Hossain, Md Amin;
- Sarin, Richa;
- Donnelly, Daniel P.;
- Miller, Brandon C.;
- Weiss, Alexandra;
- McAlary, Luke;
- Antonyuk, Svetlana V.;
- Salisbury, Joseph P.;
- Amin, Jakal;
- Conway, Jeremy B.;
- Watson, Samantha S.;
- Winters, Jenifer N.;
- Xu, Yu;
- Alam, Novera;
- Brahme, Rutali R.;
- Shahbazian, Haneyeh;
- Sivasankar, Durgalakshmi;
- Padmakumar, Swathi;
- Sattarova, Aziza;
- Ponmudiyan, Aparna C.
Publication type:
Article
Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.
Published in:
PLoS ONE, 2020, v. 15, n. 1, p. 1, doi. 10.1371/journal.pone.0227655
By:
- Crown, Anthony;
- McAlary, Luke;
- Fagerli, Eric;
- Brown, Hilda;
- Yerbury, Justin J.;
- Galaleldeen, Ahmad;
- Cashman, Neil R.;
- Borchelt, David R.;
- Ayers, Jacob I.
Publication type:
Article
Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity.
Published in:
Frontiers in Neuroscience, 2016, v. 10, p. 1, doi. 10.3389/fnins.2016.00499
By:
- McAlary, Luke;
- Aquilina, J. Andrew;
- Yerbury, Justin J.
Publication type:
Article
ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis.
Published in:
Human Molecular Genetics, 2023, v. 32, n. 14, p. 2386, doi. 10.1093/hmg/ddad063
By:
- Farrawell, Natalie E;
- Bax, Monique;
- McAlary, Luke;
- McKenna, Jessie;
- Maksour, Simon;
- Do-Ha, Dzung;
- Rayner, Stephanie L;
- Blair, Ian P;
- Chung, Roger S;
- Yerbury, Justin J;
- Ooi, Lezanne;
- Saunders, Darren N
Publication type:
Article
Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis.
Published in:
2020
By:
- McAlary, Luke;
- Plotkin, Steven S.;
- Yerbury, Justin J.;
- Cashman, Neil R.
Publication type:
Correction Notice
Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis.
Published in:
Scientific Reports, 2013, p. 1, doi. 10.1038/srep03275
By:
- McAlary, Luke;
- Yerbury, Justin J.;
- Andrew Aquilina, J.
Publication type:
Article
RNA-binding properties orchestrate TDP-43 homeostasis through condensate formation in vivo.
Published in:
Nucleic Acids Research, 2024, v. 52, n. 9, p. 5301, doi. 10.1093/nar/gkae112
By:
- Scherer, Natalie M;
- Maurel, Cindy;
- Graus, Matthew S;
- McAlary, Luke;
- Richter, Grant;
- Radford, Rowan A W;
- Hogan, Alison;
- Don, Emily K;
- Lee, Albert;
- Yerbury, Justin;
- Francois, Mathias;
- Chung, Roger S;
- Morsch, Marco
Publication type:
Article
The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04114-x
By:
- Capper, Michael J.;
- Wright, Gareth S. A.;
- Barbieri, Letizia;
- Luchinat, Enrico;
- Mercatelli, Eleonora;
- McAlary, Luke;
- Yerbury, Justin J.;
- O'Neill, Paul M.;
- Antonyuk, Svetlana V.;
- Banci, Lucia;
- Hasnain, S. Samar
Publication type:
Article
Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises.
Published in:
Frontiers in Cellular Neuroscience, 2020, v. 14, p. N.PAG, doi. 10.3389/fncel.2020.581907
By:
- McAlary, Luke;
- Chew, Yee Lian;
- Lum, Jeremy Stephen;
- Geraghty, Nicholas John;
- Yerbury, Justin John;
- Cashman, Neil R.
Publication type:
Article
Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells.
Published in:
Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-32835-y
By:
- Pokrishevsky, Edward;
- McAlary, Luke;
- Farrawell, Natalie E.;
- Zhao, Beibei;
- Sher, Mine;
- Yerbury, Justin J.;
- Cashman, Neil R.
Publication type:
Article
Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E.
Published in:
Molecular Neurodegeneration, 2020, v. 15, n. 1, p. 1, doi. 10.1186/s13024-020-00366-8
By:
- Robert, Jerome;
- Button, Emily B.;
- Martin, Emma M.;
- McAlary, Luke;
- Gidden, Zoe;
- Gilmour, Megan;
- Boyce, Guilaine;
- Caffrey, Tara M.;
- Agbay, Andrew;
- Clark, Amanda;
- Silverman, Judith M.;
- Cashman, Neil R.;
- Wellington, Cheryl L.
Publication type:
Article

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