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- Title
Atividade antibacteriana e efeito interativo in vitro de um produto a base de cranberry sobre Escherichia coli.
- Authors
Ramalho Catão, Raïssa Mayer; Nunes, Luanne Eugênia; Porto Viana, Anna Paula; Vieira da Rocha, Wilma Raianny; Dantas de Medeiros, Ana Cláudia
- Abstract
Products derived from plants are being studied because often have substances with antimicrobial activity, mainly due to the increase in bacterial resistance to antimicrobial compounds. Vaccinium macrocarpon Aiton, known as cranberry, is a plant native to, quite widespread in North America for its therapeutic properties, particularly in the prevention and treatment of urinary infections. This study aimed to evaluate the antibacterial activity, the minimum inhibitory concentration (MIC) and the possible interactions between a cranberry product when in association with antimicrobial agents against strains of Escherichia coli. The sensitivity profile was performed by disk diffusion using discs (Multifar ®), and the assessments of antibacterial activity and the MIC were performed using sterile filter paper discs (Cefar ®), soaked in 30 µl of the solution of cranberry, tested in different concentrations. The study of interference of cranberry solution about the effectiveness of antimicrobials was accomplished by soaking the antibiotic discs in their respective concentrations, with cranberry solution 30μL [20 mg/mL] equivalent to 0.5 MIC. The results showed that cranberry solution presented activity for all strains regardless of resistance profile of these lineages and was able to provoke different interactive effects when associated to antimicrobials. These results prove the antibacterial potential of this fruit promising possible, for studies of development of new products, however, also show that in some situations, it may interfere on the effectiveness of antimicrobials for clinical use.
- Publication
Revista de Ciências Farmacêuticas Básica e Aplicada, 2014, Vol 35, Issue 4, p723
- ISSN
1808-4532
- Publication type
Article