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- Title
Esophageal Reflux Hypersensitivity: A Comprehensive Review.
- Authors
Akinari Sawada; Sifrim, Daniel; Yasuhiro Fujiwara
- Abstract
Reflux hypersensitivity (RH) is one of the phenotypes of gastroesophageal reflux disease. The latest Rome IV defines RH as a condition with typical reflux symptoms and positive reflux-symptom association despite normal acid exposure. Subsequently, the Lyon consensus proposed detailed cutoff values for the criteria on the basis of experts’ consensus. Rome IV brought a clear-cut perspective into the pathophysiology of gastroesophageal reflux disease and the importance of esophageal hypersensitivity. This perspective can be supported by the fact that other functional gastrointestinal disorders such as irritable bowel syndrome and functional dyspepsia often overlap with RH. Although several possible pathophysiological mechanisms of esophageal hypersensitivity have been identified, there is still unmet medical needs in terms of treatment for this condition. This review summarizes the current knowledge regarding RH.
- Subjects
ROME; LYON (France); GASTROESOPHAGEAL reflux; IRRITABLE colon; ALLERGIES; ESOPHAGUS diseases; REFERENCE values
- Publication
Gut & Liver, 2023, Vol 17, Issue 6, p831
- ISSN
1976-2283
- Publication type
Article
- DOI
10.5009/gnl220373