We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cytomegalovirus, Toxoplasma gondii and Rubella Vertical Transmission Rates According to Mid-trimester Amniocentesis: A Retrospective Study.
- Authors
Margioula-Siarkou, Chrysoula; Kalogiannidis, Ioannis; Petousis, Stamatios; Prapa, Stella; Dagklis, Themistoklis; Mamopoulos, Apostolos; Prapas, Nikos; Rousso, David
- Abstract
Objective: To examine vertical transmission rates of Cytomegalovirus, Toxoplasma Gondii and Rubella infections according to amniotic fluid PCR analysis. Methods: A retrospective analysis of mid-trimester amniocenteses performed in in pregnancies with diagnosed maternal infection by Cytomegavirus (CMV), Rubella or Toxoplasma gondii during 1994-2008 was performed. Vertical transmission rates were observed according to the presence of the infectious agent's DNA in the amniotic fluid. A univariate regression model was also performed to investigate possible correlations between transmission and epidemiological parameters. Results: Overall, 7033 amniocenteses were performed during study's period, of which 166 (2.4%) with the indication of maternal infection by CMV, Rubella or Toxoplasma. Mean maternal age was 27.4 ± 2.5 years and the mean gestational age at amniocentesis was 18.7 ± 2.5 weeks. Vertical transmission was observed in 21 cases (12.7%). Transmission rate was 17.3% in cases with infection from CMV, 9.5% from Toxoplasma gondii and 7.8% from Rubella (P = .05). Maternal age was the only parameter being significantly associated with increased risk for vertical transmission (P = .04). Conclusions: According to our results, overall vertical transmission rate marginally exceeds 10%. CMV infection is characterized by relatively higher transplacental transmission rate, while increased maternal age appears to be associated with a higher risk for vertical transmission.
- Subjects
CYTOMEGALOVIRUSES; RUBELLA; COMMUNICABLE diseases; TOXOPLASMA gondii; AMNIOCENTESIS
- Publication
International Journal of Preventive Medicine, 2015, Vol 6, Issue 1, p28
- ISSN
2008-7802
- Publication type
Article
- DOI
10.4103/2008-7802.154774