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- Title
Pomegranate Flower Extract does not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats.
- Authors
Jilanchi, Sima; Nematbakhsh, Mehdi; Mazaheri, Safoora; Talebi, Ardeshir; Zolfaghari, Behzad; Pezeshki, Zahra; Eshraghi-Jazi, Fatemeh; Moeini, Maryam
- Abstract
Background: Nephrotoxicity is the major side-effect of cisplatin (CDDP), and it is reported to be gender-related. We evaluated the effects of pomegranate flower extract (PFE) as an antioxidant on CDDP-induced nephrotoxicity in female rats. Methods: Twenty-three adult female rats in four groups treated as following. Groups 1 and 2 received PFE at doses of 25 and 50 (mg/kg/day), respectively, for 9 days, and from day 3 on, they also received cisplatin (CDDP) (2.5 mg/kg) daily. Group 3 was treated as group 1 expects saline instead of PFE, and group 4 received PFE (25 mg/kg/day) alone. Results: Cisplatin alone increased the serum levels of blood urea nitrogen, creatinine, and nitrite; and kidney tissue damage score and kidney weight. However, PFE not only did not ameliorate the induced nephrotoxicity, but also aggravated renal tissue damage. Conclusions: Pomegranate extract as an antioxidant did not ameliorate CDDP-induced nephrotoxicity in female rats.
- Subjects
POMEGRANATE; EXTRACTS -- Therapeutic use; CISPLATIN; NEPHROTOXICOLOGY; PROXIMAL kidney tubules; THERAPEUTICS
- Publication
International Journal of Preventive Medicine, 2014, Vol 5, Issue 12, p1621
- ISSN
2008-7802
- Publication type
Article