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- Title
Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum.
- Authors
Liu, Ya-Ping; Fang, Sheng-Tao; Shi, Zhen-Zhen; Wang, Bin-Gui; Li, Xiao-Nian; Ji, Nai-Yun
- Abstract
Three new phenylhydrazones, penoxahydrazones A–C (compounds 1–3), and two new quinazolines, penoxazolones A (compound 4) and B (compound 5), with unique linkages were isolated from the fungus Penicillium oxalicum obtained from the deep sea cold seep. Their structures and relative configurations were assigned by analysis of 1D/2D NMR and mass spectroscopic data, and the absolute configurations of 1, 4, and 5 were established on the basis of X-ray crystallography or ECD calculations. Compound 1 represents the first natural phenylhydrazone-bearing steroid, while compounds 2 and 3 are rarely occurring phenylhydrazone tautomers. Compounds 4 and 5 are enantiomers that feature quinazoline and cinnamic acid units. Some isolates exhibited inhibition of several marine phytoplankton species and marine-derived bacteria.
- Subjects
QUINAZOLINE; PENICILLIUM; CINNAMIC acid; X-ray crystallography; MARINE phytoplankton; FUNGI
- Publication
Marine Drugs, 2021, Vol 19, Issue 1, p9
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md19010009