We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Haemostatic Profile of Patients with Chronic Liver Disease- its Correlation with Severity and Outcome.
- Authors
RAI, VARNIKA; DHAMEJA, NEERAJ; KUMAR, SANDIP; SHUKLA, JYOTI; SINGH, RAJEEV; DIXIT, VINOD KUMAR
- Abstract
Introduction: The liver plays an important role in the haemostatic system as it synthesizes the majority of coagulation factors and fibrinolytic proteins. Aim: The present study was planned to determine the range of haemostatic defects in patients of chronic liver diseases. Materials and Methods: Test performed included Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT), Thrombin Time (TT), Fibrinogen, Protein C, D Dimer and platelet count. Comparisons between groups frequencies and groups means were made using Chi square test and Student's t-test, respectively. Results: In cirrhosis group PT, aPTT, TT and D Dimer level were significantly increased compared to Chronic Hepatitis (CH) and control group (p<0.001 for all comparisons). Serum fibrinogen, Protein C and platelet count were significantly reduced in cirrhosis patients compared to CH and control group. (p<0.001 for all comparisons). All studied coagulation parameters were within normal limit in CH group. However, statistically significant difference was found in protein C and mean platelet count in CH group compared to control (p=0.03 and p<0.001 respectively). No evidence of bleeding or thrombosis was present in study group. Conclusion: In cirrhosis patients severe derangement in both anti and procoagulant factors occurs. Haemostatic profile in chronic hepatitis patient remains within normal limits.
- Subjects
HEPATITIS; HEMOSTASIS; THROMBOSIS; PATIENTS
- Publication
Journal of Clinical & Diagnostic Research, 2017, Vol 11, Issue 8, p24
- ISSN
0973-709X
- Publication type
Article
- DOI
10.7860/JCDR/2017/24975.10451