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- Title
The Effects of Antioxidant Supplementation on the Pathologic Mechanisms of Metabolic Syndrome and Cardiovascular Disease Development.
- Authors
Sharebiani, Hiva; Mokaram, Mina; Mirghani, Melika; Fazeli, Bahare; Stanek, Agata
- Abstract
In people with obesity, diabetes, and hypertension, lipid and glucose metabolism and oxidative stress generation interact. This condition, known as a "metabolic syndrome" (MetS), presents a global challenge and appears to be the underlying mechanism for the development of cardiovascular diseases (CVDs). This review is designed based on evidence indicating the pathogenic mechanisms of MetS. In detail, we will look at the mechanisms of oxidative stress induction in MetS, the effects of elevated oxidative stress levels on the condition's pathophysiology, and matters related to endothelial function. According to different components of the MetS pathophysiological network, the effects of antioxidants and endothelial dysfunction are reviewed. After considering the strategic role of oxidative stress in the pathophysiology of MetS and its associated CVDs, oxidative stress management by antioxidant supplementation seems an appropriate therapeutic approach.
- Subjects
THERAPEUTIC use of antioxidants; CARDIOVASCULAR diseases risk factors; TREATMENT effectiveness; OXIDATIVE stress; ENDOTHELIUM; METABOLIC syndrome; DIETARY supplements; DISEASE complications
- Publication
Nutrients, 2024, Vol 16, Issue 11, p1641
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16111641